KMID : 0606320040200010016
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Journal of Phamacetical Sciences Sookmyung Women s University 2004 Volume.20 No. 1 p.16 ~ p.20
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Design and Synthesis of N-(4-{1-[3-(4-tert-butylphenyl)ureido]-1-methylethyl}phenyl)methanesulfonamide as vanilloid receptor antagonists
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Jang Mi-Jung
Kim Hee-Doo
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Abstract
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N-(4-{1-[3-(4-tert-butylphenyl)ureido]-1-methylethyl}phenyl)methanesulfonamide (6) was designed, synthesized and evaluated as a vanilloid receptor antagonist. Compound 6 showed the moderate antagonist activity with IC50 value of 2.5 ¥ìM.
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